Amalgam Rx has gotten FDA approval for a rapid-response type 2 diabetes treatment. Once the disease is diagnosed, doctors typically prescribe low doses of insulin, which cannot be modified until the patient’s next appointment. For more responsive treatment, brother-sister team Ryan Sysko and Dr. Suzanne Clough developed an app, iSage Rx, that suggests regimen adjustments. The doctor doesn’t prescribe a set dosage, but rather prescribes a beginning dosage, a target glucose level, and the app. With each reading, the app adjusts dosages to move the next one closer to target. In addition, it has a variety of fun features like messaging and videos to make the process less frightening. The app works for all brands of insulin, and the entrepreneurs hope to expand their algorithmic app for treating other diseases. Sysko and Clough are also the founders of WellDoc, the company behind the BlueStar diabetes management platform.